AFC 900 Fermentor and Bioreactor Control
The ILS AFC 900 series provides stand-alone and networked
control of fermentors and bioreactors. The AFC 901 control
system works with existing or new fermentors and
bioreactors. The AFC 900 series works with benchtop,
steam-in-place, and pilot scale reactors. A 'water box' is
provided for controlling jacketed glass reactors.
Benefits
- Direct replacement for New Brunswick BioFlo 110, III,
3000, and MicroFerm control units. Simply plug in
existing reactor, stirrer, and instruments.
- AFC 900 can control new reactors either custom
designed/in-house or from vendors such as Broadley
James, HyClone, NBS, etc.
- ILS can provide custom solutions to customers that
have existing steam-in-place reactors, please contact us
with your needs.
- Separate cooling/heating water unit. Water lines are
separated from control hardware.
- Includes a variety of control loops and instruments (DO,
pH, temperature, serial RS232/422/485, analog 4-20
mA/0-10V).
- The system can include the option for direct
communication to Mettler Toledo ISM probes. ISM
probes provide direct digital communication and do not
require an external transmitter. The AFC can
communicate with pH, ORP, DO, and/or optical DO
(ODO). The AFC will collect measured values including
temperature. In addition the AFC can read the probe
serial # and perform probe calibration. Traditional
analog probes can coexist with the ISM digital probes
on the same AFC control box.
- Includes 4 or more user-controllable pumps. Users can
assign the pumps to the pH controller or simply control
the pumps through the HMI or remote OPC interface.
User can choose from fixed or variable speed pumps.
- The system can include optional gas-mixing valves for
both microbial and cell-culture applications. Similar to
the pumps, the gas-mixing valves are fully controllable
through the HMI or the remote OPC interface.
- AFC 900 is Ethernet-enable and complete external data
access is provided through Kepware® OPC servers. ILS
provides detailed documentation describing the
interface and PLC data registers. Computer-based
SCADA and HMI systems can easily access data. The
interface includes complete remote access to PID control
loops, pumps and valves.
- In addition, the control system can include additional
analog and serial interfaces. This allows for the addition
of external scales, analyzers, sensors, etc. ILS provides
the services to integrate such equipment.
- ILS provides can provide documentation and services to
meet FDA compliance for development, installation and
qualification. This includes validation documentation
services to meet FDA validation requirements for cGMP
applications.
- Can acquire data and control a variety of reactors
including B.Braun, Sartorius, Applikon, Bellco, HyClone,
etc. Suitable for bench-top to pilot-scale. An affordable,
fully-functional means to refurbish or replace existing
reactors, hardware and instruments.

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Cost-Effective Retrofitting of
Fermentation & Bioreactor
Control Systems
Do you have an existing installed
based of fermenters, such as
Sartorius/B. Braun Biostat/DCU
series, New Brunswick BioFlo Series,
Applikon 1010/1030, BioEngineering
NLF, or other brand and your vessels
and peripherals are in good shape
but the electronic controllers need
replacement or enhancement? The
AFC 900 series controller has been
designed to make retrofitting easy
at a lower cost than buying new
fermenter systems.
System Integration
Do you have a need to control
bench-top temperature loops,
steam-in-place reactors that
require updated controls, sampling
systems, separation systems,
valve sequencers/multiplexers, or
other process control loops and tie
these together into one package
with data acquisition and your own
control algorithms? ILS can quickly
understand your needs and will
design and install a neat and
affordable automation package for
you.